Welcome to John Schimenti's Lab at Cornell University in Ithaca, NY.
The Schimenti lab uses the mouse as a model to investigate the genetics of mammalian development, gametogenesis, and maintenance of genome integrity. In particular, his group studies the role of genes affecting DNA repair or replication, and how mutations of these genes predispose to cancer. Another major project in his lab concerns the genetics of chromosome recombination and segregation in meiosis. Recent work has concentrated on checkpoint mechanisms that protect against chromosome aberrations and birth defects in offspring.